Volume I „Cavity forming osteolyses of the jawbone“ Dr. Dr. (PhD-UCN) Johann Lechner
Systematic-integral effects of aseptic osteonecrosis “jaw ostitis” and “NICO” in the jaw
In the author`s practice, astonishing improvements in rheumatoid, neuralgiform complaints and other systematic diseases are observed after the cleansing of painfree, radiographically incospicuous and toothless jaw areas (NICO). These are structurally characterized by a fatty degenerative osteonecrosis of the cancellous bone. In order to clarify systemic connections, osteolytic and fatty degenerative cancellous bone was taken from a total of 17 subjects and examined for 27 immune messengers using bead-based multiplex technology. All 17 NICO samples consistently show the highest concentrations of RANTES/CCL5. The scientific literature on the causes and metastatic tendencies of breast cancer assigns RANTES a key role as a signalling agent.